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The effect of dexmedetomidine, a selective alpha 2 -adrenoceptor agonist, on ethanol withdrawal symptoms was studied in chronically ethanol-fed rats. After a 4-day ethanol intoxication period the rats were given sc injections of dexmedetomidine (3, 10, or 30 μg/kg) or saline (control group) at 10, 16, 22, and 39 h after the last dose of ethanol. The severity of ethanol withdrawal symptoms...
The effects of dexmedetomidine, a selective alpha 2 -adrenoceptor agonist, on rat sympathetic neurons were studied during a 12-day, heavy ethanol exposure. Adult male Wistar rats were given ethanol or isocaloric sucrose three times a day by intragastric intubation. Both acute (a single dose of 300 μg/kg p.o.) and chronic (100 μg/kg 2 P.O. throughout the experiment) effects of dexmedetomidine...
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