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Resistance to anticancer drugs that target DNA topoisomerase II (topo II) isoforms α and/or β is associated with decreased nuclear and increased cytoplasmic topo IIα. Earlier studies have confirmed that functional nuclear localization and export signal sequences (NLS and NES) are present in both isoforms. In this study, we show that topo II α and β bind and are imported into the nucleus by importin...
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