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Marine puffer fish accumulates tetrodotoxin (TTX) in the liver and ovary. In this study, we examined the pharmacokinetics of TTX in Takifugu rubripes by a single administration under general anesthesia at 20°C for 300min. The blood concentration–time profile showed multiple distinct phases after injection into hepatic portal vein. The area under the blood concentration–time curve (AUC) increased linearly...
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