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Although it is now well established that a substantial proportion of wild-living primates in sub-Saharan Africa harbor SIV, no study to date has examined to what extent the various species are naturally infected. In this study, we first describe the development and validation of sensitive and specific SIV antibody detection assays representing all major known primate lentiviral lineages on a panel...
We reported previously that murine L-929 cells expressing a human interferon (IFN)-γ cDNA lacking a signal peptide sequence synthesize but fail to secrete human IFN-γ and support vital replication at a reduced level. These cells also had elevated levels of IFN-inducible gene products. We show here that a similar response is seen in human cells expressing a mutated murine IFN-γ cDNA. The ability of...
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