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Aldo‐keto reductases (AKR) are a large superfamily of NADPH‐dependent oxidoreductases and play a role in detoxification of toxic metabolites. Rv2971, an AKR in Mycobacterium tuberculosis, has recently been identified as a target of isoniazid, a key first‐line drug against tuberculosis. Here, the cloning, expression, purification, crystallization and structural characterization of Rv2971 are described...
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