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Histopathological examination is one of the most important steps in evaluating prognosis of patients with neuroblastoma (NB). NB is a pediatric tumor of sympathetic nervous system and current evaluation of NB tumor histology is done according to the International Neuroblastoma Pathology Classification. The number of cells undergoing either mitosis or karyorrhexis (MK) plays an important role in this...
Neuroblastoma is a childhood cancer of the nervous system. Current prognostic classification of this disease partly relies on morphological characteristics of the cells from H&E-stained images. In this work, an automated cell nuclei segmentation method is developed. This method employs morphological top-hat by reconstruction algorithm coupled with hysteresis thresholding to both detect and segment...
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