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IntroductionAlthough most previous cognitive studies of β‐amyloidopathy in PD focused on cortical plaque deposition, recent postmortem studies point to an important role of striatal β‐amyloid plaque deposition. The aim of this study was to investigate the relative contributions of striatal and cortical β‐amyloidopathy to cognitive impairment in PD.
MethodsPatients with PD (n = 62; age, 68.9 ± 6.4...
Functional neuroimaging studies have detected abnormal limbic and paralimbic activation to emotional probes in posttraumatic stress disorder (PTSD), but few studies have examined neurochemical mechanisms that underlie functional alterations in regional cerebral blood flow. The μ-opioid neurotransmitter system, implicated in responses to stress and suppression of pain, is distributed in and is thought...
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