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The phosphodiesterase‐3B (PDE3B)‐cAMP pathway plays an important role in transducing the action of leptin in the hypothalamus. Obesity is usually associated with hyperleptinaemia and resistance to anorectic and body weight‐reducing effects of leptin. To determine whether the hypothalamic PDE3B‐cAMP pathway of leptin signalling is impaired during the development of diet‐induced obesity (DIO), we fed...
Leptin, the product of the obese gene, regulates energy homeostasis by acting primarily at the level of the hypothalamus. Leptin action through its receptor involves various pathways, including the signal transducer and activator of transcription (STAT)3, phosphatidylinositol 3‐kinase (PI3K), and phosphodiesterase 3B (PDE3B)‐cAMP signalling in the central nervous system and peripheral tissues. In...
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