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Stimulating high-frequency nonlinear oscillations of ultrasound contrast agents is helpful to distinguish microbubbles from background tissues. Nevertheless, inefficiency of such oscillations from most commercially available contrast agents and intense attenuation of the resultant high-frequency harmonics limit microbubble detection with high-frequency ultrasound. To avoid this high-frequency nature,...
Contrast-assisted techniques that quantitatively estimate time-intensity curves (TICs) within the perfusion area have been applied in many disease models. In this study, we monitored the microbubble replenishment by a proposed new approach called the time-Nakagami-parameter curve (TNC) obtained from Nakagami-parameter images for quantifying the microvascular flow velocity. The feasibility of using...
Chronic degenerative Achilles tendinopathy (tendonitis) is a common clinical problem and its aetiology remains in part unexplained. For the treatment of Achilles tendinopathy, there were a lot of modalities including medication, physical agents, physiotherapy, and exercise. However, how to evaluate the effects of current therapeutic modalities and study the therapeutic mechanism in vivo remains a...
Because of the overwhelming scattering of light in biological tissues, the spatial resolution and imaging depth of conventional fluorescent imaging is unsatisfactory. Therefore, we present a dual modality imaging technique by combining fluorescence imaging with high-resolution noninvasive photoacoustic tomography (PAT) for the study of an animal tumor model. PAT provides high-resolution structural...
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