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Oxygen‐Bridged Quasi‐Planar para‐Phenylenediamine and its Oxidized States

Koshi Yoshida, Kai Hikida, Takayuki Tanaka, Shu Seki, więcej

European Journal of Organic Chemistry > 27 > 22 > n/a - n/a

A quasi‐planar N, N, N’,N’‐tetraphenyl‐para‐phenylenediamine, where all the phenyl rings are tethered by four oxygen atoms to embed quasi‐planar triphenylamine moieties into the molecular skeleton, was prepared and characterized to evaluate the impact by incorporating the structural rigidity. The monocationic and dicationic species could be selectively generated, depending on the type of oxidizing...

artykuł

Cover Image, Volume 43, Number 4, April 2024

Yuichi Ishizuka, Yohei Satake, Shingo Kimura, Shinichi Yamashita, więcej

Neurourology and Urodynamics > 43 > 4 > i - i

Cover: The cover image is from the Basic Science Article Statin administration ameliorates ischemia‐induced overactive bladder with improvement of blood flow and anti‐inflammatory effects in rats by Ishizuka Y, Satake Y, Kimura S, et al. Neurourol Urodyn. 2024;43(4):991‐1002. https://doi.org/10.1002/nau.25433. Figure 2. Bladder blood flow is decreased in the AI group, and statin administration improves...

artykuł

Statin administration ameliorates ischemia‐induced overactive bladder with improvement of blood flow and anti‐inflammatory effects in rats

Yuichi Ishizuka, Yohei Satake, Shingo Kimura, Shinichi Yamashita, więcej

Neurourology and Urodynamics > 43 > 4 > 991 - 1002

Aims Statins are widely used to treat dyslipidemia and have been shown to reduce the risk of ischemic heart disease and cerebrovascular disease. The effects of statins on ischemia‐induced overactive bladder (OAB) and the associated mechanisms were investigated in a rat model of chronic pelvic ischemia. Methods A pelvic ischemia model was created by iliac arterial injury (AI) and a high‐fat diet...

artykuł

Summary of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma 2023 by the Japanese Urological Association

Kazuyuki Mori, Shingo Hatakeyama, Hideki Enokida, Hideaki Miyake, więcej

International Journal of Urology > 31 > 3 > 194 - 207

This article is an English translation of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma (2nd edition) published in June 2023. The Japanese Urological Association's (JUA) Guidelines Committee on Upper Tract Urothelial Carcinoma (UTUC) created a 2023 update guideline to support clinicians' current evidence‐based management of UTUC and to incorporate its recommendations into clinical...

artykuł

Intravenously engrafted human multilineage‐differentiating stress‐enduring (Muse) cells rescue erectile function after rat cavernous nerve injury

Juntaro Koyama, Shinichi Yamashita, Yuya Kato, Kunihisa Nezu, więcej

BJU International > 133 > 3 > 332 - 340

Objective To evaluate the effect of intravenous administration of human multilineage‐differentiating stress‐enduring (Muse) cells on rat postoperative erectile dysfunction (ED) with cavernous nerve (CN) injury without an immunosuppressant. Materials and Methods Male Sprague–Dawley rats were randomised into three groups after CN crush injury. Either human‐Muse cells, non‐Muse mesenchymal stem cells...

artykuł

CD271 promotes proliferation and migration in bladder cancer

Shingo Myoen, Mai Mochizuki, Rie Shibuya‐Takahashi, Haruna Fujimori, więcej

Genes to Cells > 29 > 1 > 73 - 85

Bladder cancer is a urothelial cancer and effective therapeutic strategies for its advanced stages are limited. Here, we report that CD271, a neurotrophin receptor, promotes the proliferation and migration of bladder cancer cells. CD271 knockdown decreased proliferation in both adherent and spheroid cultures, and vice versa when CD271 was overexpressed in bladder cancer cell lines. CD271 depletion...

artykuł

Prostate‐specific antigen follow‐up and management for patients undergoing holmium laser enucleation of the prostate

Shingo Kimura, Hiromichi Katayama, Eiichiro Ohara, Hiroshi Aoki, więcej

International Journal of Urology > 31 > 1 > 82 - 87

Objectives To investigate who needs a careful postoperative monitoring for prostate cancer (PCa) after holmium laser enucleation of the prostate (HoLEP). We examined characteristics and oncological outcomes of HoLEP‐related PCa. Methods Patients who underwent HoLEP during 2002–2017 in a Japanese tertiary center were retrospectively analyzed. Patients were divided into non‐PCa, PCa with HoLEP specimen...

artykuł

Improving compliance with guidelines may lead to favorable clinical outcomes for patients with non‐muscle‐invasive bladder cancer: A retrospective multicenter study

Takuma Sato, Takeshi Sano, Sadafumi Kawamura, Yoshihiro Ikeda, więcej

International Journal of Urology > 30 > 12 > 1155 - 1163

Objectives Clinical guidelines recommend that patients with non‐muscle‐invasive bladder cancer (NMIBC) should be treated with appropriate adjuvant therapy. However, compliance with guideline recommendations is insufficient, and this may lead to unfavorable outcomes. We aimed to investigate the level of adherence to guideline recommendations in patients with NMIBC and evaluate the outcomes of those...

artykuł

Sexual function using the EORTC QLQ‐TC26 in testicular cancer survivors: A multi‐institutional, cross‐sectional study

Juntaro Koyama, Shinichi Yamashita, Kenichi Kakimoto, Motohide Uemura, więcej

International Journal of Urology > 30 > 11 > 1044 - 1050

Objective To evaluate sexual function after treatment using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Testicular Cancer 26 (EORTC QLQ‐TC26) questionnaire in Japanese testicular cancer (TC) survivors in a multi‐institutional, cross‐sectional study. Methods This study enrolled TC survivors who visited any of eight high‐volume institutions in Japan...

artykuł

Trends in the use of local intervention for metastatic hormone‐naïve prostate cancer: A multicenter retrospective study

Ryuma Tanaka, Shingo Hatakeyama, Shintaro Narita, Toshihiko Sakurai, więcej

International Journal of Urology > 30 > 11 > 969 - 976

Objective To evaluated the trends of local intervention and their impact on oncological outcomes in metastatic hormone‐naïve prostate cancer (mHNPC) in real‐world practice. Methods This retrospective multicenter study included 760 patients treated with either androgen deprivation therapy (ADT) without local treatment (no castration‐resistant prostate cancer [CRPC] progression within 12 months,...

artykuł

C‐reactive protein as a prognostic predictor for non‐muscle invasive bladder cancer after intravesical bacillus Calmette‐Guérin therapy: A Japan Urological Oncology Group study analysis

Ryoma Nishikawa, Makito Miyake, Shuichi Morizane, Ryutaro Shimizu, więcej

International Journal of Urology > 30 > 3 > 299 - 307

Objective To investigate the involvement of pretreatment C‐reactive protein (CRP) and neutrophil‐to‐lymphocyte ratio (NLR) in the prognosis of patients who underwent intravesical bacillus Calmette‐Guérin (BCG) therapy for non‐muscle invasive bladder cancer (NMIBC). Methods The clinicopathological data of 1709 patients with NMIBC who underwent initial intravesical BCG therapy after transurethral...

artykuł

Minimal residual membranous urethral length and membranous urethral length predict poor recovery from incontinence after robot‐assisted radical prostatectomy and after open radical prostatectomy

Eiichiro Ohara, Naoki Kawamorita, Yohei Satake, Yasuhiro Kaiho, więcej

International Journal of Urology > 29 > 12 > 1517 - 1523

Objectives To investigate how much minimal residual membranous urethral length (mRUL) and maximal urethral length (MUL) measured on MRI preoperatively affect postoperative urinary incontinence (PUI) and recovery in robot‐assisted radical prostatectomy (RARP) and open radical prostatectomy (ORP). Methods The subjects were 190 and 110 patients undergoing RARP and ORP, respectively, in our institution...

artykuł

Association of financial toxicity with quality of life in testicular cancer survivors

Kunihisa Nezu, Shinichi Yamashita, Kenichi Kakimoto, Motohide Uemura, więcej

International Journal of Urology > 29 > 12 > 1526 - 1534

Objectives Most testicular cancer (TC) survivors have long‐term survival. However, the association between financial toxicity (FT), which is an economic side effect of cancer treatment, and the quality of life (QOL) of TC survivors is still unclear. Thus, the impact of FT on the QOL of TC survivors was examined in a multi‐institutional cross‐sectional study. Methods We recruited TC survivors from...

artykuł

Cancer‐specific and net overall survival in older patients with de novo metastatic prostate cancer initially treated with androgen deprivation therapy

Shintaro Narita, Naoki Terada, Kyoko Nomura, Shinichi Sakamoto, więcej

International Journal of Urology > 29 > 10 > 1147 - 1154

Objective This study aimed to assess survival outcomes in older patients with de novo metastatic prostate cancer who initially received androgen deprivation therapy. Methods The retrospective multicenter study included 2784 men with metastatic prostate cancer who were treated with androgen deprivation therapy between 2008 and 2017. Patients were classified into <75, 75–79, and ≥80 age groups...

artykuł

Neurogenic lower urinary tract dysfunction in association with severity of degenerative spinal diseases: Short‐term outcomes of decompression surgery

Shingo Kimura, Shunichi Takyu, Naoki Kawamorita, Takashige Namima, więcej

LUTS: Lower Urinary Tract Symptoms > 14 > 5 > 346 - 357

Objectives Cervical myelopathy (CM) and lumbar canal stenosis (LCS) are common degenerative spinal diseases among the elderly, and the major associated complaints include lower urinary tract symptoms (LUTS). The aim of this study was to investigate subjective and objective urological parameters of patients undergoing decompression surgery for CM and LCS. Methods We retrospectively reviewed patients...

artykuł

Effect of upfront intensive therapy on oncological outcomes in older patients with high tumor burden metastatic castration‐sensitive prostate cancer: A multicenter retrospective study

Yuki Miura, Shingo Hatakeyama, Shintaro Narita, Takahiro Kimura, więcej

The Prostate > 82 > 13 > 1304 - 1312

Background The effect of upfront intensive therapy on the prognosis of older patients with metastatic castration‐sensitive prostate cancer (mCSPC) remains unclear. Thus, we assessed the impact of older age (≥75 years) on oncological outcomes in mCSPC patients with a high tumor burden. Methods This multicenter retrospective study included 252 patients aged ≥75 years treated with either upfront or...

artykuł

Impact of Gleason pattern 5 on prognosis for newly diagnosed metastatic hormone‐sensitive prostate cancer with Gleason score ≥8

Kento Morozumi, Koji Mitsuzuka, Shintaro Narita, Masahiro Takahashi, więcej

International Journal of Urology > 29 > 4 > 324 - 331

Objective We evaluated the impact of Gleason pattern 5 presence on prognosis among de novo metastatic hormone‐sensitive prostate cancer patients with a Gleason score ≥8. Methods The data of 559 patients diagnosed as metastatic hormone‐sensitive prostate cancer with a Gleason score ≥8, who were initially treated with androgen deprivation therapy from 2008 to 2016, were retrospectively collected...

artykuł

Characteristics of α2,3‐sialyl N‐glycosylated PSA as a biomarker for clinically significant prostate cancer in men with elevated PSA level

Tohru Yoneyama, Hayato Yamamoto, Mihoko Sutoh Yoneyama, Yuki Tobisawa, więcej

The Prostate > 81 > 16 > 1411 - 1427

Background The presence of glycosylated isoforms of prostate‐specific antigen (PSA) in prostate cancer (PC) cells is a potential marker of their aggressiveness. We characterized the origin of α2,3‐sialylated prostate‐specific antigen (S23PSA) by tissue‐based sialylation‐related gene expression and studied the performance of S23PSA density (S23PSAD) alone and in combination with multiparametric magnetic...

artykuł

Fertility and reproductive technology use in testicular cancer survivors in Japan: A multi‐institutional, cross‐sectional study

Shinichi Yamashita, Kenichi Kakimoto, Motohide Uemura, Takeshi Kishida, więcej

International Journal of Urology > 28 > 10 > 1047 - 1052

Objective To evaluate fertility and use of reproductive technology of testicular cancer survivors in a multi‐institutional, cross‐sectional study. Methods This study recruited testicular cancer survivors who were followed after treatment for testicular cancer at eight high‐volume institutions between 2018 and 2019. The participants completed the questionnaires on marital status, fertility and use...

artykuł

Impact of cytoreductive nephrectomy in patients with primary metastatic renal cell carcinoma receiving systemic tyrosine kinase inhibitor therapy: A multicenter retrospective study

Shingo Hatakeyama, Sei Naito, Kazuyuki Numakura, Renpei Kato, więcej

International Journal of Urology > 28 > 4 > 369 - 375

Objectives To compare overall survival between patients with metastatic renal cell carcinoma treated by cytoreductive nephrectomy and those not treated by cytoreductive nephrectomy. Methods We retrospectively evaluated 278 patients with metastatic renal cell carcinoma treated with first‐line tyrosine kinase inhibitors between January 2008 and November 2019. Patients were divided into two groups:...

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