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We studied the relevance of adenomatous polyposis coli (APC)/β-catenin signalling in the development of breast cancer by analysing the expression of β-catenin in 54 primary breast tumours (34 ductal and 20 lobular). We showed that 13% of the tumours exhibited upregulated levels of β-catenin in the cytosol suggesting that defects in APC/β-catenin signalling components had lowered the rate of β-catenin...
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