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Abnormalities in vascular endothelial function play an important role in the development of septic organ dysfunction. The aim of this study was to examine the effect of recombinant thrombomodulin (rTM) on leukocyte-endothelial interaction and subsequent malcirculation in endotoxemia.Wistar rats were administered with either low, medium or high dose of rTM (n=7 each) 2hours after lipopolysaccharide...
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