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The HS3ST1 gene controls endothelial cell production of HSAT+ – a form of heparan sulfate containing a specific pentasaccharide motif that binds the anticoagulant protein antithrombin (AT). HSAT+ has long been thought to act as an endogenous anticoagulant; however, coagulation was normal in Hs3st1−/− mice that have greatly reduced HSAT+ (HajMohammadi et al., 2003). This finding indicates that HSAT+...
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