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Background
In atopic dermatitis (AD), phosphodiesterase 4 (PDE4) inhibition reduces proinflammatory mediators and cytokines. Difamilast is a new selective PDE4 inhibitor.
Objectives
To demonstrate the superiority of topical difamilast to vehicle in Japanese paediatric patients with AD.
Methods
This was a phase III randomized, double‐blind, vehicle‐controlled trial. Patients aged 2–14 years with...
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