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To test the safety of a single intracavernous injection of a plasmid vector (hMaxi-K) that expresses the hSlo gene, that encodes the α-subunit of the Maxi-K channel, for the treatment of erectile dysfunction (ED).Six men, thus far have fulfilled the entry criteria of the protocol and had gene transfer with hMaxi-K. Three received a dose of 500μg and three received a dose 1000μg of the gene product,...
Recent evidence indicates that the large conductance, voltage dependent, Ca 2+ sensitive K channel or Maxi-K has an important role in the modulation of human corporeal smooth muscle tone and, thus, in erectile capacity. We further clarified the contribution of the Maxi-K channel subtype to the generation of contractile responses in isolated human corporeal tissue strips. We performed pharmacological...
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