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The 4N1K peptide, which is derived from the C-terminal domain of thrombospondin-1 (TSP-1), is usually used as a functional mimic peptide for TSP-1. Knowledge about the interaction force of 4N1K/CD47 is important in explaining how TSP-1 affects the biological effect of CD47. Here we used a single-molecule force spectroscopy (SMFS) technique to explore the interaction of 4N1K/CD47 on both normal and...
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