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The aim of this work was to examine whether the non-insulin-dependent diabetic Goto–Kakizaki (GK) rats develop retinal changes with similar characteristics to those observed in insulin-dependent diabetic rats in what concerns blood–retinal barrier (BRB) permeability, nitric oxide (NO) production, and retinal IL-1β level. BRB permeability was evaluated by vitreous fluorophotometry. NO synthase (NOS)...
Several evidences suggest that the pro-inflammatory cytokines IL-1β and the radical NO are implicated as effectors molecules in the pancreatic β-cells dysfunction; an event preceding the pathogenesis of diabetes. IL-1β induces the expression of the inducible isoform of NO synthase (iNOS), which use l-arginine as substrate to overproduce NO. However, it is not known whether these events may participate...
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