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Ultrastructural three-dimensional reconstruction indicates that deposition of amyloid in the wall of capillaries and in perivascular plaques in APP SW transgenic mice (Tg2576) represents two steps of one pathological process associated with inflammation of the vascular wall and perivascular space with cells of monocyte/microglia lineage and fibrillar amyloid-β deposition. Plaque growth is...
Ultrastructural reconstruction of 27 fibrillar plaques in different stages of formation and maturation was undertaken to characterize the development of fibrillar plaques in the brains of human APP SW transgenic mice (Tg2576). The study suggests that microglial cells are not engaged in Aβ removal and plaque degradation, but in contrast, are a driving force in plaque formation and development...
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