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Biopharmaceuticals, including therapeutic antibodies, are rapidly growing products in the pharmaceutical market. Mammalian cells, such as Chinese hamster ovary (CHO) cells, are widely used as production hosts because recombinant antibodies require complex three‐dimensional structures modified with sugar chains. Recombinant protein production using mammalian cells is generally performed with cell growth...
Retrotransposons, such as long interspersed element‐1 (LINE‐1), can copy themselves to other genomic loci via a transposition event (termed retrotransposition). Retrotransposons, therefore, have potential use as an efficient gene delivery tool to integrate multiple copies of a target gene into a host genome. Here, we developed a retrotransposon vector based on LINE‐1 that achieves target gene integration...