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P-glycoprotein (P-gp), as an ATP-binding cassette transporter, can transport a variety of substrates across the cell membrane in human and animals, even in aquatic animals. Multixenobiotic resistance phenomenon (MXR) related to the P-gp has been identified and characterized in several aquatic organisms, however, the nature of this transporter and the structural basis for the resistance are still poorly...
Nile tilapia, Oreochromis niloticus, is one of the most important cultivated species in freshwater aquaculture due to its fast growth rate. microRNAs (miRNAs) are approximately 22-nt noncoding RNAs that have emerged as key regulators of skeletal muscle development, but the knowledge of the identity of myogenic miRNAs and their targets in tilapia remains limited. Here, we identify 25 conserved miRNAs...
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