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Idiopathic Parkinson's disease (PD) is characterized by mesencephalic dopaminergic neuron cell death and striatal dopamine (DA) depletion. The factors involved in the pathogenesis of the disease are still unknown. Transforming growth factor β1 (TGFβ1) is increased in the striatum of patients with PD. However, the effect of this increase is not known. Here, we show that overexpression of TGFβ1, by...
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