Search results for: Akitane Mori

Items from 1 to 20 out of 37 results

article

The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism

Lijing Zhao, Xingyu Zhao, Kai Zhao, Peng Wei, more

European Journal of Pharmacology > 2014 > 745 > Complete > 98-107

Cancer cells are known to exhibit different hallmarks compared with normal cells. Therefore, targeting these features may improve the response to cancer therapy. In this study, we provided direct evidence that the α-tocopherol derivative ESeroS-GS inhibited the viability, migration, and invasion of breast cancer cells. ESeroS-GS induced cell death in different cancer cells in a dose-dependent manner...

article

ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts

Wenjuan Duan, Juefei Zhou, Shen Zhang, Kai Zhao, more

BBA - Molecular Cell Research > 2011 > 1813 > 5 > 772-783

The binding of lipopolysaccharides (LPS) to macrophages results in inflammatory responses. In extreme cases it can lead to endotoxic shock, often resulting in death. A broad range of antioxidants, including tocopherols, can reduce LPS activity in vitro and in vivo. To elucidate the underlying mechanisms of their action, we investigated the effect of the sodium salt of γ-L-glutamyl-S-[2-[[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]carbonyl]-3-[[2-(1H-indol-3-yl)ethyl]amino]-3-oxopropyl]-L-cysteinylglycine...

article

Docosahexaenoic Acid Ethyl Ester Enhances 6-Hydroxydopamine-Induced Neuronal Damage by Induction of Lipid Peroxidation in Mouse Striatum

Hideaki Kabuto, Masao Amakawa, Mitsumasa Mankura, Tomoko T. Yamanushi, more

Neurochemical Research > 2009 > 34 > 7 > 1299-1303

Superoxide and hydroxyl radicals are implicated in the pathogenesis of Parkinson disease, and induction of lipid peroxidation is an important factor in progression of this disease. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. However, DHA has neuroprotective effects. In this study, we examined the effects...

article

Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures

Toshiki Masumizu, Yasuko Noda, Akitane Mori, Lester Packer

Brain Research Protocols > 2005 > 16 > 1-3 > 65-69

As an index of oxidative status, we analyzed ascorbyl radical generation during and after kainate-induced seizures in mouse hippocampus, using an ESR spectrometer equipped with a special tissue-type quartz cell. A specific doublet ESR spectrum was observed after seizures, and the g value and the hyperfine coupling constant (hfcc) of the spectrum were identical with those of ascorbyl radical itself...

article

The antioxidant ESeroS-GS inhibits NO production and prevents oxidative stress in astrocytes

Taotao Wei, Xingyu Zhao, Jingwu Hou, Kazumi Ogata, more

Biochemical Pharmacology > 2003 > 66 > 1 > 83-91

Within the central nervous system uncontrolled production of large amounts of nitric oxide (NO) by activated glial cells might be the common pathogenesis of several neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In the present investigation, we measured the effect of a novel antioxidant γ-l-glutamyl-S-[2-[[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltri...

article

Antioxidant Activities of Pomegranate Fruit Extract and Its Anthocyanidins: Delphinidin, Cyanidin, and Pelargonidin

Yasuko Noda, Takao Kaneyuki, Akitane Mori, Lester Packer

Journal of Agricultural and Food Chemistry > 2002 > 50 > 1 > 166 - 171

article

Effects of magnetic fields on the accumulation of thiobarbituric acid reactive substances induced by iron salt and H2O2 in mouse brain homogenates or phosphotidylcholine

Hideaki Kabuto, Isao Yokoi, Norio Ogawa, Akitane Mori, more

Pathophysiology > 2001 > 7 > 4 > 283-288

In this study, we examined the effects of magnetic fields (MFs) on the generation of thiobarbituric acid reactive substances (TBARS) in the mouse brain homogenates or phosphotidylcholine (PC) solution, incubated with FeCl ₃ and/or H ₂ O ₂ . Active oxygen species were generated and lipid peroxidation was induced in mouse brain homogenates by incubation with iron ions, resulting...

article

Nitric oxide induces oxidative stress and apoptosis in neuronal cells

Taotao Wei, Chang Chen, Jingwu Hou, Wenjuan Xin, more

BBA - Molecular Cell Research > 2000 > 1498 > 1 > 72-79

Within the central nervous system and under normal conditions, nitric oxide (NO) is an important physiological signaling molecule. When produced in large excess, NO also displays neurotoxicity. In our previous report, we have demonstrated that the exposure of neuronal cells to NO donors induced apoptotic cell death, while pretreatment with free radical scavengers L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopy...

article

Antioxidant activity of nasunin, an anthocyanin in eggplant peels

Yasuko Noda, Takao Kneyuki, Kiharu Igarashi, Akitane Mori, more

Toxicology > 2000 > 148 > 2-3 > 119-123

The free radical scavenging activities and inhibitory effect of lipid peroxidation of a delphinidin derivative in eggplant were investigated. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple colored crystals from eggplant peels. Using electron spin resonance spectrometry and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), hydroxyl radicals (OH) or superoxide...

article

Preface

Toshikazu Yoshikawa, Akitane Mori

Pathophysiology > 2000 > 7 > 2 > 81

article

Alternate magnetic fields potentiate monoamine oxidase activity in the brain

Isao Yokoi, Hideaki Kabuto, Yukiko Nanba, Nihei Yamamoto, more

Pathophysiology > 2000 > 7 > 2 > 121 - 125

Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] which exists two iso-enzymes named MAO-A and MAO-B. In this study, the effects of magnetic fields on MAO activity in the rat brain were examined. MAO-A activity was not changed in static magnetic fields (0.1-340 mT) or in 10-500 mT/s of alternate isosceles...

article

Magnetic fields and lipoic acid influence the respiratory burst in activated rat peritoneal neutrophils

Yasuko Noda, Akitane Mori, Robert P. Liburdy, Lester Packer

Pathophysiology > 2000 > 7 > 2 > 137 - 141

When rat (Sprague-Dawley, male) peritoneal neutrophils are exposed to 60 Hz, 1 Gauss, magnetic fields and activated by phorbor 12-myristate 13-acetate they undergo an enhanced respiratory burst (S. Roy, Y. Noda, V. Eckert, M.G. Traber, A. Mori, R.P. Liburdy, L. Packer, The phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst in rat peritoneal neutrophils is increased by a 0. 1 mT (60 Hz)...

article

Effects of an in vivo 60 Hz magnetic field on monoamine levels in mouse brain

Hideaki Kabuto, Isao Yokoi, Akitane Mori, Norio Ogawa

Pathophysiology > 2000 > 7 > 2 > 115 - 119

We studied the effects of electromagnetic fields (EMF) on mouse brain monoamine levels in models of (1) chronic exposure (7 days) of EMF (60 Hz, 10 Gauss) to mice in a vertical orientation, (2) prolonged chronic exposure (84 days) of EMF (60 Hz, 10 Gauss) to mice in a horizontal mode, (3) acute exposure (6 h) of EMF (60 Hz, 10 Gauss) to senescence accelerated mice (SAM-P8) at ages 1, 3, 6, 9 and 12...

article

Detection and a possible mechanism of magnetic field effect on the crystal growth of sedimentary calcium carbonate

Nagao Azuma, Kunihiko Tajima, Kazuhiko Ishizu, Isao Yokoi, more

Pathophysiology > 2000 > 7 > 2 > 83 - 89

Sedimentary calcium carbonate was grown at a physiological pH6.8 from a mixture of equivolume of 70 mM Ca(NO ₃ ) ₂ and 70 mM NaHCO ₃ aqueous solution. The kinetics of the crystal growth was monitored by means of turbidity measurement. The apparent absorption is gradually increased with the elapsed time after the mixing and reaches its maximum at t _m _a _x . The...

article

The magnetic field effect affecting on the metallic chemical components of egg shell as demonstrated for breeding chicken

Kazuhiko Ishizu, Hideo Hasegawa, Isao Yokoi, Akitane Mori

Pathophysiology > 2000 > 7 > 2 > 101 - 105

The chickens were raised under fixation of the permanent magnet (80 mT) and the effect of extra magnetic field, which affects on the content of the several inorganic chemical elements of egg shell, was investigated by X-ray fluorescence spectroscopy. From 3 days after fixing the magnet, the relative concentration of Ca begun to increase. After 10 days, the relative contents of Ca were decreased, while...

article

An idea for a relation between the frequency and intensity of the optimal oscillating magnetic field for the magnetic effects

Nagao Azuma, Isao Yokoi, Kunihiko Tajima, Kazuhiko Ishizu, more

Pathophysiology > 2000 > 7 > 2 > 91 - 92

An idea for a relation between the frequency and intensity of the optimal oscillating magnetic field for the magnetic effects has been presented. An estimated optimal frequency is about 150 Hz for a system containing ions of effective molecular weight of M~100 under a square pulsing magnetic field of intensity H=1 mT.

article

Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum

Yasuko Noda, Akitane Mori, Robert P. Liburdy, Lester Packer

Pathophysiology > 2000 > 7 > 2 > 127 - 130

The effect of pulsed magnetic fields on nitric oxide synthase (NOS) activity in the rat brain was investigated. Sprague-Dawley rats (male, 200-250 g body weight) brain were dissected regionally, and the crude enzyme solutions were treated with pulsed DC, AC or static DC magnetic fields at 0 ^o C for 1 h. After exposure, NOS activity was measured as nitrite and nitrate levels generated from...

article

Gliclazide scavenges hydroxyl and superoxide radicals: An electron spin resonance study

Yasuko Noda, Akitane Mori, Elaine Cossins, Lester Packer

Metabolism > 2000 > 49 > 2 Supplement 1 > 14-16

The role of reactive oxygen species in diabetes and its complications are well known. Two therapeutic agents commonly used in the treatment of diabetes are the sulfonylureas gliclazide and glibenclamide. These drugs effectively reduce blood sugar in non-insulin-dependent diabetes mellitus, by augmenting insulin release. Gliclazide is known to be a general free radical scavenger as shown by its inhibition...

article

EPC-K1 protects neuronal cells from peroxynitrite-mediated oxidative damage

Taotao Wei, Wenjuan Xin, Jingwu Hou, Chang Chen, more

Research on Chemical Intermediates > 2000 > 26 > 7-8 > 667-677

Protective effects of EPC-K1 (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyldecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt, a difunctional derivative of vitamin C and vitamin E) on neuronal cell damage mediated by peroxynitrite were studied. Primary cultures of cerebellar granule cells were exposed to peroxynitrite by treatment with 3-morpholinosydnonimine-N...

article

The antioxidant EPC-K1 attenuates NO-induced mitochondrial dysfunction, lipid peroxidation and apoptosis in cerebellar granule cells

Taotao Wei, Chang Chen, Jingwu Hou, Baolu Zhao, more

Toxicology > 1999 > 134 > 2-3 > 117 - 126

In this study we investigated the effects of nitric oxide (NO) on cultured cerebellar granule cells. Exposure to NO donors, S-nitrosoglutathione (GSNO; 250 μM) or sodium nitroprusside (SNP; 500 μM), triggered apoptosis in immature cultures of cerebellar granule cells, which was characterized by chromatin condensation, nuclei fragmentation, and DNA laddering. Exposure of cerebellar granule cells to...

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Search results for: Akitane Mori

The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism

ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts

Docosahexaenoic Acid Ethyl Ester Enhances 6-Hydroxydopamine-Induced Neuronal Damage by Induction of Lipid Peroxidation in Mouse Striatum

Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures

The antioxidant ESeroS-GS inhibits NO production and prevents oxidative stress in astrocytes

Antioxidant Activities of Pomegranate Fruit Extract and Its Anthocyanidins: Delphinidin, Cyanidin, and Pelargonidin

Effects of magnetic fields on the accumulation of thiobarbituric acid reactive substances induced by iron salt and H2O2 in mouse brain homogenates or phosphotidylcholine

Nitric oxide induces oxidative stress and apoptosis in neuronal cells

Antioxidant activity of nasunin, an anthocyanin in eggplant peels

Preface

Alternate magnetic fields potentiate monoamine oxidase activity in the brain

Magnetic fields and lipoic acid influence the respiratory burst in activated rat peritoneal neutrophils

Effects of an in vivo 60 Hz magnetic field on monoamine levels in mouse brain

Detection and a possible mechanism of magnetic field effect on the crystal growth of sedimentary calcium carbonate

The magnetic field effect affecting on the metallic chemical components of egg shell as demonstrated for breeding chicken

An idea for a relation between the frequency and intensity of the optimal oscillating magnetic field for the magnetic effects

Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum

Gliclazide scavenges hydroxyl and superoxide radicals: An electron spin resonance study

EPC-K1 protects neuronal cells from peroxynitrite-mediated oxidative damage

The antioxidant EPC-K1 attenuates NO-induced mitochondrial dysfunction, lipid peroxidation and apoptosis in cerebellar granule cells

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