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Background
The gene therapeutic Cal‐1 comprises the anti‐HIV agents: (i) sh5, a short hairpin RNA to CCR5 that down‐regulates CCR5 expression and (ii) maC46 (C46), a peptide that inhibits viral fusion with the cell membrane. These constructs were assessed for inhibition of viral replication and selective cell expansion in a number of settings.
Methods
HIV replication, selective outgrowth and cell...
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