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Abstract Using a muscle cell line and satellite cell cultures, it has been shown that transforming growth factor- (TGF-) has a powerful inhibitory effect on myoblast replication and differentiation. However, little work has been done on the possible role of TGF- in adult muscle in vivo. Using Western blot and immunohistochemical analyses, we investigated normal distribution of TGF-2 and TGF-RII proteins...
Abstract We investigated changes in several growth factors in the rat plantaris muscle produced by mechanical overloading by ablation of synergists using immunohistochemistry. At 1 and 3 days post surgery, the insulin-like growth factor-I (IGF-I) level was slightly increased in the cytosol and markedly increased in the invading cells of the extracellular space. Thereafter, the IGF-I immunoreactivity...
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