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Essentially all cells are covered with a dense coat of different glycan structures/sugar chains, giving rise to the so‐called glycocalyx. Changes in cellular glycosylation are a hallmark of cancer, affecting most of the pathophysiological processes associated with malignant transformation, including tumour immune responses. Glycans are chief macromolecules that define T‐cell development, differentiation,...
Glycans are carbohydrates that are made by all organisms and covalently conjugated to other biomolecules. Glycans cover the surface of both human cells and pathogens and are fundamental to defining the identity of a cell or an organism, thereby contributing to discriminating self from nonself. As such, glycans are a class of ‘Self‐Associated Molecular Patterns’ that can fine‐tune host inflammatory...
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