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Patients with increased numbers of cholesterol-depleted apolipoprotein B (apoB) particles frequently have multiple other abnormalities, which might confound the comparison of apoB and non–high-density-lipoprotein-cholesterol (non–HDL-C) as markers of cardiovascular risk.We wanted to determine whether the superiority of apoB over non–HDL-C as a marker of cardiovascular risk in the INTERHEART study...
Whether non-HDL-C and apoB are equivalent markers of cardiovascular risk remains controversial. Only when apoB particles in toto contain either more or less cholesterol than normal – that is, when their composition is discordant – could apoB and non-HDL-C predict risk differently. Accordingly, this study tests within the INTERHEART data base whether apoB or non-HDL-C are equivalent markers of risk...
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