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Previous studies suggest that cannabinoids system plays an important role in cardiovascular regulation. (m)VD-hemopressin(α) (VD-Hpα), an 11-residue peptide originating from the α 1 chain of hemoglobin, was recently reported as a selective agonist of cannabinoid CB 1 receptor. The present study was undertaken to investigate the intrathecal (i.t.) action of (m)VD-Hpα on blood pressure...
Salusin-β is a new regulatory peptide relevant to the cardiovascular system and exerts negative inotropic effect on ventricular muscle. The purpose of the present study was to determine whether salusin-β can inhibit cardiac L-type calcium channel current (I Ca,L ). Using whole-cell voltage-clamp techniques, I Ca,L was measured in ventricular myocytes isolated from 12 to 16 weeks rats...
Neuropeptide FF (NPFF) belongs to a neuropeptide family including two precursors (pro-NPFF A and pro-NPFF B ) and two receptors (NPFF 1 and NPFF 2 ). NPFF and NPFF receptor mRNAs have been reported to be highly expressed and localized in the rat and human spinal cord. In the present study, the i.t. action of NPFF system on blood pressure and heart rate were examined...
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