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Effects of hemodialysis on pharmacokinetic properties and QTc were studied in 4 patients taking daily methadone dose of 100 mg (range, 60–120 mg).Methadone in serum, dialysate, and urine were measured by LC-MS/MS. QTc was calculated with Bazett’s formula.The serum Cmin methadone level was 1124 nmol/L (range, 547–1581 nmol/L). Methadone dialysate clearance was 17.1 mL/min (range, 13.7–20.6 mL/min)...
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