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Media components play an important role in modulating cell metabolism and improving product titer in mammalian cell cultures. To sustain cell productivity, highly active oxidative metabolism is desired. Here we explored the effect of tricarboxylic acid (TCA) cycle intermediates supplementation on lactate metabolism and productivity in Chinese hamster ovary fed‐batch cultures. Direct addition of 5...
pH control is critical in bioreactor operations, typically realized through a two‐sided control loop, where CO2 sparging and base addition are used in bicarbonate‐buffered media. Though a common approach, base addition could compromise culture performance due to the potential impact from pH excursions and osmolality increase in large‐scale bioreactors. In this study, the feasibility of utilizing control...
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