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Gallbladder carcinoma is an aggressive cancer associated with a poor prognosis. Unfortunately, the precise molecular mechanisms of development and progression of this highly malignant tumor remain unknown. It is still unclear whether loss of heterozygosity (LOH) plays a significant role in gallbladder carcinogenesis, but recent studies have found a high incidence of LOH at several chromosomes in gallbladder...
Pancreatic cancer is a disease with a dismal outcome and a 5-year survival rate of under 5%. Recent studies have shown that pancreatic cancer consists of an accumulation of genetic and epigenetic alterations during tumor development as in other human cancers. Therefore, new diagnostic methods for early detection and more effective therapeutic strategies based on a better understanding of the molecular...
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