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Mitochondria are core regulators of tumor cell homeostasis, and their damage has become an arresting therapeutic modality against cancer. Despite the development of many mitochondrial‐targeted pharmaceutical agents, the exploration of more powerful and multifunctional medications is still underway. Herein, oxygen vacancy‐rich BiO2‐x wrapped with CaCO3 (named BiO2‐x@CaCO3/PEG, BCP) is developed for...
The therapeutic exploration of nano‐zirconia semiconductor largely remains untouched in the field of fundamental science to date. Here, a robust nano‐sonosensitizer of ZrO2−x@Pt is strategically formulated by in situ growth of Pt nanocrystal onto the surface of oxygen‐deficient ZrO2−x. Compared to 3.09 eV of nano‐ZrO2−x, the bandgap of ZrO2−x@Pt Schottky junction is narrowed down to 2.74 eV. The band...
This study was conducted to evaluate the possible involvement of mitochondrial pathway in NaAsO2-induced apoptosis and the role of reactive oxygen species (ROS) and reduced glutathione (GSH) in the apoptotic effect in Chang human hepatocytes. The MTT assay demonstrated that sodium arsenite (NaAsO2) treatment for 24 h caused a dose-dependent decrease of cell viability. NaAsO2 treatment (0–30 μM) was...
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