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The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor α (IL-4Rα) gene. In addition polymorphism occurs in the promoter for the IL-4 gene...
Although possessing a morphologically similarsmall bowel abnormality to patients with isolatedgluten-sensitive enteropathy (GSE), patients withdermatitis herpetiformis (DH) have few gastrointestinal symptoms and exhibit blistering skin lesionsand cutaneous IgA deposits. To determine whetherclinical discrepancies between these gluten-sensitiveconditions might be the result of different patterns of...
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