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Hexavalent chromium is recognized as a human carcinogen. Our previous studies revealed that lung cancer (LC) in chromate‐exposed workers (chromate LC) had molecular features of frequent microsatellite instability (MSI), repression of MLH1 level, and aberrant DNA methylation of several tumor‐suppressor genes, including MLH1. In the present study, we quantitatively investigated MLH1‐promoter methylation...
Our previous studies revealed a variety of genetic changes in lung cancers from chromate‐exposed workers (chromate lung cancer). In the present study, we examined epigenetic changes in chromate lung cancers. Nested‐methylation‐specific PCR was employed in studying the methylation of CpG islands in the APC, MGMT, hMLH1 genes in 36 chromate lung cancers and 25 nonchromate lung cancers. Methylation in...
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