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Contrary to the reduction of depressive-like behavior observed in several strains of cytokine receptor knockout mice, mice lacking the specific receptor for interleukin (IL)-15 showed increased immobility in tail suspension and modified forced swimming tests. There was also a reduction in social interactions. The hippocampus of the IL15Rα knockout mice had decreased mRNA for 5-HT 1A , increased...
Interleukin (IL)-15 can cross the blood–brain barrier to act on its specific brain receptor (IL15Rα) and co-receptors. The important roles of neuronal IL15 and IL15Rα in experimental autoimmune encephalomeylitis (EAE) are suggested by the upregulation of IL15Rα mRNA in different regions of the brain and spinal cord, and by double-labeling immunohistochemistry showing neuronal localization of IL15...
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