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IL‐34 is a recently discovered cytokine that acts on tissue resident macrophages and Langerhans cells upon binding the receptor for CSF‐1, CSF‐1R. The existence of two ligands for CSF‐1R, IL‐34, and CSF‐1, raises several intriguing questions. Are IL‐34 and CSF‐1 redundant or does each perform temporally and spatially distinct functions? Is IL‐34 involved in human pathology? Would therapeutic strategies...
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