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The hallmark of chronic viral infections is a progressive exhaustion of antigen‐specific CD8+ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8+ T cells that makes them dysfunctional. Here, we show that during human chronic HIV‐1 infection, a CD8+ T‐cell positive costimulatory pathway...
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