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Serine proteinases such as mast cell tryptase, trypsin-like enzymes, and certain allergens are important in the pathogenesis of asthma. These proteinases can activate the proteinase-activated receptor (PAR)–2, which has been shown to be upregulated in the airways of patients with asthma.The purpose of this study was to investigate PAR-2 activation in the airways during allergen challenge and its effects...
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