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The MED1 subunit of the Mediator transcriptional coregulator complex coactivates GATA1 and induces erythropoiesis. Here, we show the dual mechanism of GATA1‐ and MED1‐mediated transcription. MED1 expression levels in K562 erythroleukemia cells paralleled the levels of GATA1‐targeted gene transcription and erythroid differentiation. An N‐terminal fragment of MED1, MED1(1–602), which is incapable of...
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