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Parasites that are molecular mimics express proteins which resemble host proteins. This resemblance facilitates immune evasion because the immune molecules with the specificity to react with the parasite also cross‐react with the host's own proteins, and these lymphocytes are rare. Given this advantage, why are not most parasites molecular mimics? Here we explore potential factors that can select...
The evolution of resistance to drugs is a major public health concern as it erodes the efficacy of our therapeutic arsenal against bacterial, viral, and fungal pathogens. Increasingly, it is recognized that the evolution of resistance involves genetic changes at more than one locus, both in cases where multiple changes are required to obtain high‐level resistance, and where compensatory changes at...
A significant goal of recent theoretical research on pathogen evolution has been to develop theory that bridges within‐ and between‐host dynamics. The main approach used to date is one that nests within‐host models of pathogen replication in models for the between‐host spread of infectious diseases. Although this provides an elegant approach, it nevertheless suffers from some practical difficulties...
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