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This research is aimed to develop a reduction-degradable micelle delivery system based on polymer-camptothecin (CPT) conjugate in order to enhance the solubility and stability of CPT in aqueous media. Firstly, disulfide-linked poly(amido amine) (SS-PAA) containing alkyne groups was synthesized by Michael addition polymerization between propargyl amine and N,N′-bis(acryloyl) cystamine (BAC). And then,...
Polysaccharide nanocrystals, such as the rod-like whiskers of cellulose and chitin, and platelet-like starch nanocrystals, were for the first time incorporated into supramolecular hydrogels based on cyclodextrin/polymer inclusion in order to enhance mechanical strength and regulate drug release behavior. The structures and properties of the resultant nanocomposite hydrogels were characterized by X-ray...
New nanocomposites of waterborne polyurethane (WPU) as a matrix were prepared by filling low loading of starch nanocrystals (StNs) as a nano-phase. It is worth noting that the resultant StN/WPU nanocomposites showed significant enhancements in strength, elongation and Young's modulus. Herein, the key role of StN in simultaneous reinforcing and toughening was disclosed, namely active surface and rigidity...
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