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Platelet-activating factor (PAF) is a phospholipid mediator of inflammation present in the human bone marrow. Freshly isolated human mononuclear bone marrow cells and marrow stromal cell cultures produced PAF under calcium ionophore (2µM) and LPS (10 µg/ml) stimulation. By contrast M-CSF (1000 U/ml), GM-CSF (100 ng/ml), IL1. IL3, IL6 and stem cell factor (10 ng/ml) did not stimulate PAF production...
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