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The anticancer drug 5-fluorouracil-1-acetic acid was covalently attached to -cyclodextrin at the secondary hydroxyl side by using N, N -carbonyldiimidazole as a coupling reagent. The preliminary release behaviors of 5-fluorouracil-1-acetic acid in the gastrointestinal tract fluids of rats were studied at 37 ?. 5-Fluorouracil-1-acetic acid was almost released 52.6% from the conjugates after 24 h in...
The antimicrobial drug metronidazole was covalently attached to e-cyclodextrin by --CH2-CO-bridges. The preliminary release behavior of metronidazole in the cecal fluids of rats was studied at 37 °C. Metronidazole was nearly released 60% from the macromolecular conjugates after 24 h in the cecal fluids of rats, probably via the biodegradation by glycosidases and hydrolases.
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