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We previously showed that a trans-splicing ribozyme reprograms tumor-related genes at the mRNA level, resulting in the expression of therapeutic genes and that this approach can be efficiently employed to target specific molecules. Here, we show that trans-splicing ribozyme technology can be applied in molecular imaging of specific RNA expression in living animals. We exemplify this concept successfully...
Tumor necrosis factor α (TNFα) induces apoptosis of a variety of tumor cell types. The anti-tumor effect of TNFα is often augmented by interferon (IFN) γ. We hypothesized that IFNα, which shares many biological activities with IFNγ, might also synergize with TNFα for the induction of tumor cell death. We tested our hypothesis using ME-180 human cervical cancer cells exposed to either IFNα or TNFα...
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