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Large multimodal datasets such as The Cancer Genome Atlas present an opportunity to perform correlative studies of tissue morphology and genomics to explore the morphological phenotypes associated with gene expression and genetic alterations. In this paper we present an investigation of Cancer Genome Atlas data that correlates morphology with recently discovered molecular subtypes of glioblastoma...
Three recombinant Escherichia coli strains were constructed to produce guanosine 5'-diphosphate (GDP)-mannose, donor of GDP-fucose, which is an essential substrate for synthesis of fucosyloligosaccharides. Glucokinase (glk), phosphomannomutase (manB), and mannose-1-phosphate guanylytransferase (manC), are three crucial enzymes for the de novo GDP-mannose biosynthesis, were overexpressed in recombinant...
Arthrobacter simplex is extensively used in pharmaceutical industry to introduce C1-C2 double bond into steroid nucleus. This dehydrogenation reaction is known characterized by its 3-ketosteroid-Δ1-dehydrogenase(KSDH), which is encoded by ksdD gene. In this research, we report the expression of KSDH in Escherichia coli. The activity of the enzyme has been determined by spectrophotometric method. We...
The integration of imaging and genomic data is critical to forming a better understanding of disease. Large public datasets, such as The Cancer Genome Atlas, present a unique opportunity to integrate these complementary data types for in silico scientific research. In this letter, we focus on the aspect of pathology image analysis and illustrate the challenges associated with analyzing and integrating...
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