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Introduction: Growth factors have shown potential for inducing angiogenesis and enhancing survival in the flap tissue. Targeted gene therapy has been shown to increase the bioavailability of various growth factors. In this study, we examined the effectiveness of preoperative vascular endothelial growth factor (VEGF) plasmid DNA transfection on the survival of the skin paddle in a rat pedicled TRAM...
Introduction: Pancreatic cancer is a devastating disease. Efficacy of type I repeats of thrombospondin (TSP-1) in mice with orthotopic pancreatic cancer was tested and compared to gemcitabine.Methods: SCID mice treated with an intrapancreatic injection of a human pancreatic cancer cell line (ASPC-1) developed large orthotopic tumors with local invasion, peritoneal and and mesenteric implants. Recombinant...
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