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The effects of altering extracellular pH on late Na + currents were investigated in large dorsal root ganglion neurons from rats (100-300g), using patch-clamp techniques. The late current amplitude was steeply dependent upon pH over a range which included normal physiological values: raising the pH from 7.3 to 8.3 approximately doubled the amplitude. Whole-cell late currents 60ms after depolarization...
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