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Abstract
Gestational hypoxia adversely affects uterine artery function, increasing complications. However, an effective therapy remains unidentified. Here, we show in rodent uterine arteries that hypoxic pregnancy promotes hypertrophic remodelling, increases constrictor reactivity via protein kinase C signalling, and triggers compensatory dilatation via nitric oxide‐dependent mechanisms and stimulation...
Key pointsExposure to microgravity induces postflight orthostatic intolerance on re‐exposure to 1 G gravity which is second to the structural and functional remodelling of arteries.We found the maximal developed force (Emax) of angiotensin II‐elicited vasoconstriction was decreased in abdominal aorta, unchanged in thoracic aorta and increased in carotid artery by simulated weightlessness. However,...
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