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Hypoxic Tumor Therapy
In article number 2200786, Lili Feng, He Ding, Piaoping Yang, and co‐workers develop a near‐infrared (NIR)–triggered nanoplatform with controlled release of a heat shock proteins (HSPs) inhibitor for synergistic mild photothermal and enhanced Fenton nanocatalysis. Upon NIR irradiation, gambogic acid is released and inhibits the expression of HSP90. Notably, the nanoplatform simultaneously...
Mild photothermal therapy (PTT, <45 °C) can prevent tumor metastasis and heat damage to normal tissue, compared with traditional PTT (>50 °C). However, its therapeutic efficacy is limited owing to the hypoxic tumor environment and tumor thermoresistance owing to the overproduction of heat shock proteins (HSPs). Herein, a near‐infrared (NIR)‐triggered theranostic nanoplatform (GA‐PB@MONs@LA)...
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