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The impact of the insertion (I)/deletion (D) (I/D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene on the extent of white matter myelin loss (ML) was investigated in four regions of the cerebral cortex in an autopsy-confirmed series of 93 patients with Alzheimer's disease (AD). The possible influence of APO E ε4 allele acting in concert with ACE D allele was assessed. The extent of...
Cerebral amyloid angiopathy (CAA) is an important, though still relatively neglected, aspect of the pathology of Alzheimer's disease (AD), and both the source of amyloid β protein (Aβ) in CAA, and its relationship to senile plaque (SP) Aβ, remain unclear. We have investigated the relationship between Aβ deposition in SP and CAA in four regions of brain from 69 patients with AD in order to gain insight...
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