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Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen receptor α (ERα) in mediating estrogen-dependent bone maintenance in female mice. We selectively ablated ERα in differentiated osteoclasts (ERα ΔOc/ΔOc ) and found that ERα ΔOc/ΔOc females, but not males,...
Myeloproliferative syndromes (MPS) are a heterogeneous subclass of nonlymphoid hematopoietic neoplasms which are considered to be intrinsic to hematopoietic cells. The causes of MPS are largely unknown. Here, we demonstrate that mice deficient for retinoic acid receptor γ (RARγ), develop MPS induced solely by the RARγ-deficient microenvironment. RARγ −/− mice had significantly increased granulocyte/macrophage...
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